2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
This article is all about what AI trends will emerge in the field of creative operations in 2024. All the marketers and brand builders should be aware of these trends for their further use and save themselves some time!
A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
It’s important that you’re ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
You’ll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summarySpeakerHub
From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.
A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.
Time Management & Productivity - Best PracticesVit Horky
Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.
The six step guide to practical project managementMindGenius
The six step guide to practical project management
If you think managing projects is too difficult, think again.
We’ve stripped back project management processes to the
basics – to make it quicker and easier, without sacrificing
the vital ingredients for success.
“If you’re looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.”
Dr Andrew Makar, Tactical Project Management
Unlocking the Power of ChatGPT and AI in Testing - A Real-World Look, present...Applitools
During this webinar, Anand Bagmar demonstrates how AI tools such as ChatGPT can be applied to various stages of the software development life cycle (SDLC) using an eCommerce application case study. Find the on-demand recording and more info at https://applitools.info/b59
Key takeaways:
• Learn how to use ChatGPT to add AI power to your testing and test automation
• Understand the limitations of the technology and where human expertise is crucial
• Gain insight into different AI-based tools
• Adopt AI-based tools to stay relevant and optimize work for developers and testers
* ChatGPT and OpenAI belong to OpenAI, L.L.C.
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
This article is all about what AI trends will emerge in the field of creative operations in 2024. All the marketers and brand builders should be aware of these trends for their further use and save themselves some time!
A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
It’s important that you’re ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
You’ll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summarySpeakerHub
From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.
A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.
Time Management & Productivity - Best PracticesVit Horky
Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.
The six step guide to practical project managementMindGenius
The six step guide to practical project management
If you think managing projects is too difficult, think again.
We’ve stripped back project management processes to the
basics – to make it quicker and easier, without sacrificing
the vital ingredients for success.
“If you’re looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.”
Dr Andrew Makar, Tactical Project Management
Unlocking the Power of ChatGPT and AI in Testing - A Real-World Look, present...Applitools
During this webinar, Anand Bagmar demonstrates how AI tools such as ChatGPT can be applied to various stages of the software development life cycle (SDLC) using an eCommerce application case study. Find the on-demand recording and more info at https://applitools.info/b59
Key takeaways:
• Learn how to use ChatGPT to add AI power to your testing and test automation
• Understand the limitations of the technology and where human expertise is crucial
• Gain insight into different AI-based tools
• Adopt AI-based tools to stay relevant and optimize work for developers and testers
* ChatGPT and OpenAI belong to OpenAI, L.L.C.
2. La miastenia grave (MG) es un trastorno autoinmune relativamente rara de los nervios periféricos Una reducción en el número de receptores de acetilcolina en los resultados de un patrón característico de la fuerza muscular reducida progresivamente con el uso repetido del músculo y la recuperación de la fuerza muscular después de un período de descanso. http://emedicine.medscape.com/article/793136-overview http://cariobat.files.wordpress.com/2010/03/myastheniagravis.jpg
3. Los pacientes se vuelven sintomáticos cuando el número de receptores de acetilcolina se reduce a aproximadamente el 30% de lo normal. Los receptores colinérgicos del músculo liso y cardíaco tienen una antigenicidad diferente al músculo esquelético y no son afectadas por la enfermedad. http://emedicine.medscape.com/article/793136-overview http://esclerodermia-adec.org/sistem1.jpg
4. la miastenia gravis no tratados llevado a una tasa de mortalidad del 30-70%. En la era moderna, los pacientes con miastenia grave tienen una esperanza de vida casi normal. La razón hombre / mujer de la miastenia gravis en niños y adultos es de 2:3 MORTALIDAD Y MORBILIDAD http://emedicine.medscape.com/article/793136-overview
5. MEDIOS DE DIAGNOSTICO Los exámenes que pueden realizarse son: anticuerpos del receptor de acetilcolina (puede estar presente en la sangre) TC o IRM del tórax (puede mostrar un tumor en el timo) La estimulación repetitiva (un tipo de estudio de conducción nerviosa, pueden ser más sensibles) EMG de fibra única (puede ser muy sensible) http://www.google.com.co/images?hl=es&source=imghp&biw=1090&bih=466&q=MEDIOS+DE+DIAGNOSTICO&btnG=Buscar+im%C3%A1genes&gbv=2&aq=f&aqi=&aql=&oq=&gs_rfai= http://www.google.com.co/images?hl=es&source=imghp&biw=1090&bih=466&q=MEDIOS+DE+DIAGNOSTICO&btnG=Buscar+im%C3%A1genes&gbv=2&aq=f&aqi=&aql=&oq=&gs_rfai=
7. • La causa de la miastenia gravis se desconoce, pero es claramente una enfermedad autoinmune en la que el anticuerpo específico se ha caracterizado por completo. En hasta un 90% de los casos generalizados, IgG contra el receptor nicotínico de Ach es present.4 • Las mujeres y las personas con determinado antígeno leucocitario humano (HLA) los tipos tienen una predisposición genética a las enfermedades autoinmunes. http://emedicine.medscape.com/article/793136-overview
8. La miastenia gravis es causada por un problema en la transmisión de señales nerviosas a los músculos. Normalmente, las terminaciones nerviosas liberan una sustancia que se adhiere a los receptores en los músculos. Eso le dice a los músculos a contraerse. Si tiene miastenia gravis, el cuerpo propio sistema inmunológico produce anticuerpos para bloquear esa señal. http://www.nlm.nih.gov/medlineplus/myastheniagravis.html http://medciclopedia.com/wp-content/uploads/image/debilidad2.jpg
10. ¿QUIEN PADECE LA MIASTENIA GRAVIS? http://espanol.ninds.nih.gov/trastornos/miastenia_gravis.htm
11. TRATAMIENTO No se conoce ninguna cura para la miastenia gravis. Sin embargo, el tratamiento puede dar lugar a períodos prolongados sin síntomas (remisión). ajustes de estilo de vida por lo general permite la continuación de muchas actividades. La actividad debe ser planificada para permitir períodos de descanso. Un parche en el ojo se puede recomendar si la visión doble es molesta. El estrés y la exposición excesiva al calor se deben evitar porque pueden empeorar los síntomas. Algunos medicamentos, como neostigmina o piridostigmina, mejoran la comunicación entre el nervio y el músculo. Prednisona u otros medicamentos (como la azatioprina, ciclosporina o micofenolato mofetilo) que inhiben la respuesta autoinmune responsable de la debilidad puede ser utilizado si los síntomas son severos y otros medicamentos no funcionan lo suficientemente bien.
12. BACKGROUND AND OBJECTIVE: Recently, the presence of antibodies to a muscle-specific tyrosine kinase (MuSK) has been reported in some patients with seronegative generalized myasthenia gravis. Our objective was to describe a group of patients who were positive for anti-MuSK antibodies. PATIENTS AND METHOD: Detection of antibodies using a radioimmunoassay was performed in the serum of 26 patients with generalized myasthenia gravis. We identified 9 patients with anti-MuSK antibodies (MuSK+). Clinical and therapeutic data from these patients were reviewed. RESULTS: Eight of nine patients were women aged between 20 and 40 years. Clinically, all of them showed prevalent bulbar signs, initially or during the progression of the disease. 77% of patients showed ocular involvement and 44% had symptoms of fatigability involving limbs. None of them improved upon thymectomy. Response to acetylcholinesterase inhibitors was variable. All of them responded to immunotherapy, although 30% required polytherapy. CONCLUSIONS: The study of anti-MuSK antibodies defines a subgroup of patients, 34,61% in our series, with seronegative generalized myasthenia. This group is characterized by an homogenous clinical presentation with prevalent bulbar symptoms. The knowledge of the immunopathogenic mechanisms of anti-MuSK antibodies will allow a better understanding of both the variable response to acetylcholinesterase inhibitors and the absence of response to thymectomy in these patients. http://www.ncbi.nlm.nih.gov/sites/entrez
13. Fundamento y objetivo: Recientemente, la presencia de anticuerpos frente a una tirosina quinasa específica del músculo (almizcle) ha sido reportado en algunos pacientes con miastenia grave generalizada seronegativa. Nuestro objetivo fue describir un grupo de pacientes que fueron positivos para anticuerpos anti-almizcle. Pacientes y método: La detección de anticuerpos mediante un radioinmunoensayo se llevó a cabo en el suero de 26 pacientes con miastenia grave generalizada. Se identificaron 9 pacientes con anticuerpos anti-almizcle (almizcle +). Los datos clínicos y terapéuticos de estos pacientes fueron revisados. RESULTADOS: Ocho de los nueve pacientes eran mujeres con edades comprendidas entre 20 y 40 años. De vista clínico, todos ellos presentaban signos frecuentes bulbar, en un principio o durante la progresión de la enfermedad. 77% de los pacientes presentaban afectación ocular y el 44% presentó síntomas de fatiga participación de los miembros. Ninguno de ellos mejorado timectomía. Respuesta a los inhibidores de la acetilcolinesterasa fue variable. Todos ellos respondieron a inmunoterapia, aunque el 30% requirió politerapia. CONCLUSIONES: El estudio de anticuerpos anti-almizcle define un subgrupo de pacientes, 34,61% en nuestra serie, con miastenia generalizada seronegativa. Este grupo se caracteriza por una presentación homogénea con síntomas clínicos prevalentes bulbar. El conocimiento de los mecanismos inmunopatológicos de anticuerpos anti-MuSK permitirá una mejor comprensión tanto de la respuesta variable a los inhibidores de la acetilcolinesterasa y la ausencia de respuesta a la timectomía en estos pacientes. http://www.ncbi.nlm.nih.gov/sites/entrez
14. IgG Fc N-Glycosylation Changes in Lambert-Eaton Myasthenic Syndrome and Myasthenia Gravis N-glycosylation of the immunoglobulin Fc moiety influences its biological activity by, for example, modulating the interaction with Fc receptors. Changes in IgG glycosylation have been found to be associated with various inflammatory diseases. Here we evaluated for the first time IgG Fc N-glycosylation changes in well-defined antibody-mediated autoimmune diseases, that is, the neurological disorders Lambert-Eaton myasthenic syndrome and myasthenia gravis, with antibodies to muscle nicotinic acetylcholine receptors or muscle-specific kinase. IgGs were purified from serum or plasma by protein A affinity chromatography and digested with trypsin. Glycopeptides were purified and analyzed by MALDI-FTICR−MS. Glycoform distributions of both IgG1 and IgG2 were determined for 229 patients and 56 controls. We observed an overall age and sex dependency of IgG Fc N-glycosylation, which was in accordance with literature. All three disease groups showed lower levels of IgG2 galactosylation compared to controls. In addition, LEMS patients showed lower IgG1 galactosylation. Notably, the galactosylation differences were not paralleled by a difference in IgG sialylation. Moreover, the level of IgG core-fucosylation and bisecting N-acetylglucosamine were evaluated. The control and disease groups revealed similar levels of IgG Fc core-fucosylation. Interestingly, LEMS patients below 50 years showed elevated levels of bisecting N-acetylglucosamine on IgG1 and IgG2, demonstrating for the first time the link of changes in the level of bisecting N-acetylglucosamine with disease. http://pubs.acs.org/doi/abs/10.1021/pr1004373
15. Cambios IgG Fc N-glicosilación en el síndrome de Lambert-Eaton Miasténico y la Miastenia Gravis N-glicosilación de la fracción Fc de inmunoglobulina influye en su actividad biológica, por ejemplo, la modulación de la interacción con los receptores Fc. Los cambios en la glicosilación de IgG se han encontrado para ser asociado con diversas enfermedades inflamatorias. Aquí se evaluó por primera vez IgG Fc N-glicosilación en los cambios bien definidos enfermedades autoinmunes mediadas por anticuerpos, es decir, los trastornos neurológicos síndrome de Lambert-Eaton y la miastenia gravis, con anticuerpos contra receptores nicotínicos de acetilcolina del músculo o de músculos específicos-quinasa . IgG se purificaron a partir de suero o plasma por cromatografía de afinidad con proteína y digerido por la tripsina. Glicopéptidos fueron purificados y analizados por MALDI-FTICR-MS. Glycoform distribuciones de ambos IgG1 e IgG2 se determinaron para 229 pacientes y 56 controles. Se observó un total en edad de sexo y la dependencia de IgG Fc N-glicosilación, que estaba de acuerdo con la literatura. Los tres grupos de enfermedades mostraron niveles más bajos de IgG2 galactosilación comparación con los controles. Además, los pacientes mostraron menor SMEL galactosilación IgG1. En particular, las diferencias galactosilación no han ido por una diferencia de sialilación IgG. Además, el nivel del núcleo de IgG fucosylation y bisectriz N-acetilglucosamina se evaluaron. El control y grupos de enfermedades revelaron niveles similares de IgG Fc-fucosylation núcleo. Curiosamente, SMEL pacientes menores de 50 años mostraron niveles elevados de N-acetilglucosamina bisectriz de IgG1 e IgG2, lo que demuestra por primera vez el vínculo de los cambios en el nivel de N-acetilglucosamina bisectriz con la enfermedad. http://pubs.acs.org/doi/abs/10.1021/pr1004373
16. Lambert-Eaton myasthenic syndrome as a cause of persistent neuromuscular weakness after a mediastinoscopic biopsy -A case report-. There are many causes of prolonged postoperative muscle weakness, including drugs, residual anesthetics, cerebrovascular events, electrolyte imbalance, hypothermia, and neuromuscular disease. Neuromuscular diseases are relatively rare, with the most common being myasthenia gravis and Lambert-Eaton myasthenic syndrome (LEMS). We report an unusual case in which a patient who was given a muscle relaxant during mediastinoscopy developed postoperative muscle weakness that was ultimately diagnosed as secondary to LEMS http://www.ncbi.nlm.nih.gov/pubmed/20651998
17. El síndrome de Lambert-Eaton como causa de la persistente debilidad neuromuscular después de una biopsia mediastinoscopic de un caso Hay muchas causas de la prolongada debilidad muscular postoperatorio, incluyendo medicamentos, anestésicos residuales, eventos cerebrovasculares, el desequilibrio electrolítico, la hipotermia y enfermedades neuromusculares. Las enfermedades neuromusculares son relativamente raros, con la miastenia grave y más común es el síndrome de Lambert-Eaton (SMEL). Presentamos un caso inusual en el que un paciente que se le dio un relajante muscular durante la mediastinoscopia desarrolló debilidad muscular postoperatoria, que fue diagnosticado en última instancia, como secundaria a SMEL http://www.ncbi.nlm.nih.gov/pubmed/20651998
18. Myathenia Graviswithrippling muscles desease Myathenia Graviswithrippling muscles diseasePosted on 05:27PM (EDT) on 2010-08-01I was diagnosed with Myasthenia Gravis in 2006. It was surprisingn when I hd so much pain in my eyes. I could not keep them open. I was weak all the time and had to take steroids, then later Mestinon. Gradually I got stronger and took less Mestinon. I do not smoke or drink and live a healthy life. I am 65.A year ago, I was diagnosed, along with MG (4 years ago), with Rippling muscles disease, a disease few doctors knoanything about. I am going to University of Texas Southwest in Dallas and have the best neurologists but they are just in the dark as to what to do with this rippling muscle disease. They research it all the time.The pain and rippling phenomenon started in my arm and now it is all over my body. I had my thymus taken out a few years ago, hoping the MG would go away in time. Instead, this rippling muscle thing turned up a few years later.I can only compare it to 'severe' charlie horses' in my neck to my back to my shoulders, down in my arms, to my buttocks, to both legs. I grow weak ,can't stand confidently, wobble and just endure the pain.It is like a tight rubber band with no elasticity. I have to wait and tell my legs to move, or to lift themselves. The muscles will not do so on their own.Some days it is a 10 (severe) while some days I can bear it at a 3- 4. I understand there are only 8 people in the world that have this so no money is in research. Heat is dangerous for me so I have to stay in doors a lot.I am taking IVIG treatments as a last resort every two weeks at 6 hrs each treatment. It will take time to see if it will help the pain and the settling of the muscles. It is extremely expensive and if Obama cuts that out for those of us that take it, I am in a pickle. I decline very quickly.Does anyone out there have anything like this? WHat are your treatments? Are they successful or not? How do you cope? It is a tough thing to deal with along with the MG. By the way, all those that have rippling muscles dis. also have MG. Doctors are trying to link the two together. I hope there is an answer soon.I am interested in your prognosis, your treatment and how you cope?thanks. http://www.revolutionhealth.com/blogs/fisherman3/myathenia-graviswithr-21696
19. Myathenia músculos Graviswithrippling enfermedad Publicado el 17:27 (EDT) del 01/08/2010 Me diagnosticaron con Miastenia Gravis en 2006. Fue cuando me surprisingn hd tanto dolor en mis ojos. Yo no podía mantenerlos abiertos. Yo era débil todo el tiempo y tuvo que tomar esteroides, luego Mestinon. Poco a poco me hizo más fuerte y tomó menos Mestinon. No fumar ni beber y vivir una vida sana. Tengo 65. Hace un año, me diagnosticaron, junto con MG (4 años), con la enfermedad de los músculos de ondulación, la enfermedad de unos pocos médicos saben nada al respecto. Voy a la Universidad de Texas Sudoeste en Dallas y tienen las mejores neurólogos pero son sólo en la oscuridad en cuanto a qué hacer con esta enfermedad del músculo ondulante. Ellos investigan todo el tiempo. El dolor y la ondulación fenómeno comenzó en el brazo y ahora es todo mi cuerpo. Tuve mi timo sacado hace unos años, esperando que la MG se iría en el tiempo. En su lugar, esta cosa del músculo ondulante apareció un año más tarde. Sólo puedo compararlo con los caballos graves Charlie "en el cuello a mi espalda a los hombros, en mis brazos, a mis nalgas, en ambas piernas. Crezco débil, no puede soportar con seguridad, balanceo y sólo soportar la pain.It es como una goma elástica apretada sin elasticidad. Tengo que esperar y les digo a mis piernas para moverse, o para que ellos mismos. Los músculos no lo hará por su cuenta. Hay días que es un 10 (graves), mientras que algunos días podré soportarlo en un 3 a 4. Entiendo que hay sólo 8 personas en el mundo que tienen este modo no hay dinero en la investigación. El calor es peligroso para mí así que tengo que permanecer en las puertas de un lote. Hago uso de tratamientos IVIG como último recurso, cada dos semanas a 6 horas cada tratamiento. Hará falta tiempo para ver si le ayudan con el dolor y la fijación de los músculos. Es muy caro y si los recortes a Obama que para aquellos de nosotros que tome, estoy en un aprieto. Yo rechazo muy rápidamente. ¿Alguien por ahí tiene algo como esto? ¿Cuáles son sus tratamientos? ¿Son o no éxito? ¿Cómo hacer frente? Es algo difícil de abordar, junto con el MG. Por cierto, todos los que han dis ondulación músculos. También han MG. Los médicos están tratando de vincular los dos juntos. Espero que haya una respuesta pronto. Yo estoy interesado en su pronóstico, su tratamiento y cómo hacer frente? gracias. Myathenia músculos Graviswithrippling enfermedad http://www.revolutionhealth.com/blogs/fisherman3/myathenia-graviswithr-21696